Glutathione is an antioxidant made from glycine, glutamic acid and cysteine. It is a strong antioxidant for cleaning of the liver, removal of toxic substances from the body and sharpening of the brains. Like any other drug side effects glutathione inhibits production of melanin hence lightens the skin and many people have used as an advantage in getting a fair skin. Glutathione lightens skin in several ways. It works by
These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders. The presence of Glutathione is required by the body to maintain normal function of the immune system. Glutathione is involved in detoxification by binding to toxins like heavy metals, solvents, pesticides and transforms them into a form that can be excreted in urine. It neutralizes the harmful effects of free radicals. Glutathione can be found in many healthy foods that people eat on a regular basis like walnuts, avocados, tomatoes and oranges can all help to keep Glutathione levels high in the bloodstream. Glutathione is commonly taken in pill form, and Glutathione pills are hugely successful in Japan, particularly for women that just want to have lighter skin than they were born with without the side effects that some topical treatments have. Glutathione works to clear the body of free radicals and toxins that can lead to serious skin problems like hyperpigmentation and melasma, as well as more common ones like sun spots. Glutathione can be extremely beneficial for people that would just prefer a slightly lighter complexion. In fact, many women that have flawless skin use Glutathione on a regular basis to help maintain their excellent complexion.
- Direct inactivation of the enzyme tyrosinase by binding and chelating copper within the enzyme’s active site
- Mediating the switch mechanism from eumelanogenesis to pheomelanogenesis, as glutathione participates in the conversion of dopaquinone to pheomelanin. The observed differences in the glutathione and glutathione-related enzyme content between black and yellow (or red) skin provide evidence that the increase of glutathione-reductase activity in the environment of the melanocytes may stimulate the pigment cells to produce phaeomelanin instead of eumelanin pigment. As expected, the lowest levels of reduced glutathione (GSH) were found associated with eumelanin type pigmentation, whereas the highest ones were found in the skin with phaeomelanin producing melanocytes;
- Quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation;
- Modulation of depigmenting abilities of melanocytotoxic agents.
- Research results also indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA. The balance between CysH and GSH, which is partly determined by the rate of utilization of CysH for GSH biosynthesis, regulates not only the levels of 5-S-CD and DOPA but also the melanogenic activity of pigment cells. Since DOPA functions as a cofactor in the monophenolase reaction of tyrosinase, it is proposed that the ratio of 5-S-CD to DOPA may be an important factor in the regulation of tyrosinase activity.
These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders. The presence of Glutathione is required by the body to maintain normal function of the immune system. Glutathione is involved in detoxification by binding to toxins like heavy metals, solvents, pesticides and transforms them into a form that can be excreted in urine. It neutralizes the harmful effects of free radicals. Glutathione can be found in many healthy foods that people eat on a regular basis like walnuts, avocados, tomatoes and oranges can all help to keep Glutathione levels high in the bloodstream. Glutathione is commonly taken in pill form, and Glutathione pills are hugely successful in Japan, particularly for women that just want to have lighter skin than they were born with without the side effects that some topical treatments have. Glutathione works to clear the body of free radicals and toxins that can lead to serious skin problems like hyperpigmentation and melasma, as well as more common ones like sun spots. Glutathione can be extremely beneficial for people that would just prefer a slightly lighter complexion. In fact, many women that have flawless skin use Glutathione on a regular basis to help maintain their excellent complexion.
No comments:
Post a Comment