Monobenzone is the monobenzyl ether of hydroquinone a depigmenting agent. Similar to hydroquinone, monobenzyl ether of hydroquinone (MBEH) belongs to the phenol/catechol class of chemical agents. Genarally monobenzone is used on skin to permanently lighten skin in people with vitiligo. Depigmenting darker skin around the areas of vitiligo helps even out coloring and appearance of the skin. Due to its depigmenting effect, it is also used for skin whitening.
Mechanism of Action: Exact mechanisn is unknown but it is theorized that It works by eliminating melanin (pigment molecules) from skin cells by selective melanocytic destruction through free-radical formation and competitive inhibition of the tyrosinase enzyme system. Unlike hydroquinone, MBEH almost always causes nearly irreversible depigmentation of the skin.
It may take up to 4 months to complete the depigmentation of treated skin. It causes uneven pigmentation on skin when applied topically. So users have to use it carefully with expert’s advice. Skin treated with monobenzone makes skin sensitive to sunlight which leads to easy sunburn. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. In dermatology, MBEH is only used to eliminate residual areas of normally pigmented skin in patients with generalized vitiligo.
Mechanism of Action: Exact mechanisn is unknown but it is theorized that It works by eliminating melanin (pigment molecules) from skin cells by selective melanocytic destruction through free-radical formation and competitive inhibition of the tyrosinase enzyme system. Unlike hydroquinone, MBEH almost always causes nearly irreversible depigmentation of the skin.
It may take up to 4 months to complete the depigmentation of treated skin. It causes uneven pigmentation on skin when applied topically. So users have to use it carefully with expert’s advice. Skin treated with monobenzone makes skin sensitive to sunlight which leads to easy sunburn. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. In dermatology, MBEH is only used to eliminate residual areas of normally pigmented skin in patients with generalized vitiligo.
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